SmartPeak Automates Targeted and Quantitative Metabolomics Data Processing

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Targeted, LCMS-based Metabolomics for Quantitative Measurement of NAD+ Metabolites

Nicotinamide adenine dinucleotide (NAD(+)) is a coenzyme for hydride transfer reactions and a substrate for sirtuins and other NAD(+)-consuming enzymes. The abundance of NAD (+), NAD(+) biosynthetic intermediates, and related nucleotides reflects the metabolic state of cells and tissues. High performance liquid chromatography (HPLC) followed by ultraviolet-visible (UV-Vis) spectroscopic analysi...

متن کامل

Targeted metabolomics for bioprocessing

Background Bioprocesses like the cell-based production of biologicals, i.e. mainly recombinant proteins and monoclonal antibodies, require optimal culture conditions to obtain a high yield of quality products. The performance of a bioreactor highly depends on the cell characteristics as well as on the composition of the cell culture medium and the process conditions. As the metabolic activity o...

متن کامل

Quantitative Comparison of Statistical Methods for Analyzing Human Metabolomics Data

1Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 2Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 3Departments of Medicine & Pharmacology, University of California San Diego, La Jolla, CA 4Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 5Preventive Medicine, Department of Medicine,...

متن کامل

MassCascade: Visual Programming for LC-MS Data Processing in Metabolomics

Liquid chromatography coupled to mass spectrometry (LC-MS) is commonly applied to investigate the small molecule complement of organisms. Several software tools are typically joined in custom pipelines to semi-automatically process and analyse the resulting data. General workflow environments like the Konstanz Information Miner (KNIME) offer the potential of an all-in-one solution to process LC...

متن کامل

Variation in the human lipidome associated with coffee consumption as revealed by quantitative targeted metabolomics.

The effect of coffee consumption on human health is still discussed controversially. Here, we report results from a metabolomics study of coffee consumption, where we measured 363 metabolites in blood serum of 284 male participants of the Cooperative Health Research in the Region of Augsburg study population, aged between 55 and 79 years. A statistical analysis of the association of metabolite ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Analytical Chemistry

سال: 2020

ISSN: 0003-2700,1520-6882

DOI: 10.1021/acs.analchem.0c03421